Laboratory diagnosis of Disseminated Intravascular Coagulation (DIC): A case series

Abstract

Background: Disseminated intravascular coagulation (DIC) is a complex acquired syndrome characterized by systemic activation of coagulation pathways, leading to widespread fibrin deposition in the microvasculature, consumption of platelets and coagulation factors, and subsequent bleeding tendency. Laboratory diagnosis is essential for confirming DIC, assessing its severity, and monitoring therapeutic response. The International Society on Thrombosis and Haemostasis (ISTH) has established standardized diagnostic criteria combining clinical findings with specific laboratory parameters to improve diagnostic accuracy [1,2] . This case series aims to illustrate and evaluate the utility and variability of these common laboratory parameters in the diagnosis of DIC across diverse patient cases.