Inflammatory bowel disease with ankylosing spondylitis and autoimmune overlap

Abstract

Background: Inflammatory bowel disease (IBD) is frequently associated with extraintestinal manifestations, including musculoskeletal and autoimmune disorders. We report a case of a 56-year-old female with known ulcerative colitis presenting with acute flare of bowel symptoms and inflammatory back pain, found to have ankylosing spondylitis with HLA-B27 positivity and autoimmune serological markers including ANCA and anti-Ro52 positivity, suggesting a complex autoimmune overlap.