Double primary malignancy: Bilateral breast carcinoma in a patient with past history of papillary thyroid carcinoma

Abstract

Background: Double primary malignancy is defined as the occurrence of two independent primary cancers in the same individual. With improved cancer survival and better diagnostic techniques, the incidence of multiple primary malignancies has increased. We report a case of a 50-year-old female with a past history of papillary thyroid carcinoma who later developed bilateral invasive breast carcinoma. The patient presented with a right breast lump and was diagnosed with bilateral breast malignancy on imaging and biopsy. She received neoadjuvant chemotherapy followed by bilateral modified radical mastectomy with axillary lymph node dissection. Final histopathology revealed invasive carcinoma of no special type (NST) in both breasts with residual cancer burden class II. This case highlights the importance of multidisciplinary management in patients with complex oncological conditions involving multiple primary tumors.